Article
The guanine nucleotide exchange factor Rin-like is a repressor for renal uric acid excretion in human and mouse.
Science translational medicine - 23 Sept 2026
Han Changshun, He Chengyong, Hu Weiping, Chen Zhiyuan, Ding Xiaoyan, Ye Lingxiao, Zhu Sihao, Zhong Lin, Zhuang Shuni, Peng Tianyun, Li Zixuan, He Pan, Lin Lirong, Ren Yingyi, Ruan Fengkai, Wang Zizhen, Zhang Yan, Zhang Fucong, Guo Yitao, Yang Chunyan, Zhang Baoding, Wang Wei, Li Changgui, Wang Bo, Li Jian, Zhang Chensong, Deng Xianming, Zuo Zhenghong
Abstract excerpt
The prevalence of hyperuricemia (HUA) is increasing annually and now affects ∼14% of the population. Uric acid (UA) is the end product of purine metabolism in humans. Either increased production or reduced excretion of UA can induce HUA. Here, we identified RAS and RAB interactor-like (RINL) as a regulator of renal UA excretion and conducted a screen for compounds capable of lowering serum UA concentrations. We...
Read the complete abstract on PubMedTopics
- Humans
- Animals
- Uric Acid
- Guanine Nucleotide Exchange Factors