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Article

hURAT1 Transgenic Mouse Model for Evaluating Targeted Urate-Lowering Agents.

International journal of rheumatic diseases - 1 Jan 2025

Cai Weiyan, Yang Miyi, Zhao Qinghe, Yi Guohua, Lin Peihui, Chen Apeng, De Gejing

Abstract excerpt

BACKGROUND: Urate transporter 1 (URAT1) is a well-known therapeutic target for reducing urate levels in the treatment of hyperuricemia and gout. However, current pharmacological studies have failed to evaluate the efficacy of URAT1 inhibitors in non-primate animal models. We established a human URAT1 (hURAT1) transgenic knock-in (KI) mouse model to assess uricosuric agents' effectiveness and characterize...

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Identifiers

PMID: 39740040
DOI: 10.1111/1756-185X.70034

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