Article
Depletion of perineuronal nets enhances recognition memory and long-term depression in the perirhinal cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Apr 2013
Romberg Carola, Yang Sujeong, Melani Riccardo, Andrews Melissa R, Horner Alexa E, Spillantini Maria G, Bussey Timothy J, Fawcett James W, Pizzorusso Tommaso, Saksida Lisa M
Abstract excerpt
Perineuronal nets (PNNs) are extracellular matrix structures surrounding cortical neuronal cell bodies and proximal dendrites and are involved in the control of brain plasticity and the closure of critical periods. Expression of the link protein Crtl1/Hapln1 in neurons has recently been identified as the key event triggering the formation of PNNs. Here we show that the genetic attenuation of PNNs in adult brain...
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