Article

Differentiation-Dependent Proximity Proteomics Identifies Novel Host Factors Linked to HPV16 E2 Function

2025-10-22

Abstract excerpt

Human papillomavirus 16 (HPV16) is a causative agent of oropharyngeal, cervical and anogenital cancers. The viral E2 protein is essential for viral genome replication, transcriptional regulation, episome maintenance, and activation of the host DNA damage response. Despite its central role, the full network of HPV16 E2 interactions with host proteins remains incompletely defined, particularly under differentiating...

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Literature Corpus work: 04d5c81b-2957-5936-9635-50e2aba0cecf
DOI: 10.1101/2025.10.21.683683

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