Article

E6AP is important for HPV E6’s role in regulating epithelial homeostasis and its loss impairs keratinocyte commitment to differentiation

2022-06-26

Abstract excerpt

Human papillomaviruses (HPV) typically cause chronic infections by modulating homeostasis of infected basal cell to ensure persistence. Using FUCCI and cell-cell competition assays, we established the role of two common viral targets of low-risk and high-risk E6 proteins, E6AP and NHERF1, on four key components of epithelial homeostasis. These includes cell density, proliferation, commitment to differentiation and...

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Literature Corpus work: 2d83c09a-f9b4-5f89-9bd8-51fa0107872a
DOI: 10.1101/2022.06.23.497250

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