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Article

Disruption of CTCF-YY1–dependent looping of the human papillomavirus genome activates differentiation-induced viral oncogene transcription

25 Oct 2018

Abstract excerpt

The complex life cycle of oncogenic human papillomavirus (HPV) initiates in undifferentiated basal epithelial keratinocytes where expression of the E6 and E7 oncogenes is restricted.Upon epithelial differentiation, E6/E7 transcription is increased through unknown mechanisms to drive cellular proliferation required to support virus replication.We report that the chromatin-organising CCCTC-binding factor (CTCF)...

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PMID: 30359362
DOI: 10.1371/journal.pbio.2005752

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