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Article

Genetic dysfunction of serotonin 2A receptor hampers response to antidepressant drugs: A translational approach.

Neuropharmacology - 1 Jun 2016

Qesseveur Gaël, Petit Anne Cécile, Nguyen Hai Thanh, Dahan Lionel, Colle Romain, Rotenberg Samuel, Seif Isabelle, Robert Pauline, David Denis, Guilloux Jean-Philippe, Gardier Alain M, Verstuyft Céline, Becquemont Laurent, Corruble Emmanuelle, Guiard Bruno P

Abstract excerpt

Pharmacological studies have yielded valuable insights into the role of the serotonin 2A (5-HT2A) receptor in major depressive disorder (MDD) and antidepressant drugs (ADs) response. However, it is still unknown whether genetic variants in the HTR2A gene affect the therapeutic outcome of ADs and the mechanism underlying the regulation of such response remains poorly described. In this context, a translational...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26764241
DOI: 10.1016/j.neuropharm.2015.12.022

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