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Super-Resolution Imaging Reveals Stretch-Induced Architectural Rearrangement of Desmoplakin in Desmosomes

2025-08-27

Abstract excerpt

Desmosomes (DSMs) are intercellular junctions essential for providing mechanical resilience to tissues, particularly the epidermis. Desmoplakin (DP) is a key DSM protein which anchors plaque proteins to keratins, thereby ensuring tissue integrity under mechanical stress. Clinically, DP mutations impair keratinocyte adhesion and structural integrity, leading to skin fragility disorders. However, how mechanical forc...

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Literature Corpus work
9e3ba066-8546-5bda-83ae-7b8dd656288d
DOI
10.1101/2025.08.26.672431
Open publication

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Super-Resolution Imaging Reveals Stretch-Induced Architectural Rearrangement of Desmoplakin in DesmosomesDOI 10.1101/2025.08.26.672431
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