Article

Clustering of desmosomal cadherins by desmoplakin is essential for cell-cell adhesion

2020-04-06

Abstract excerpt

<h4>ABSTRACT</h4> Desmoplakin (Dp) localizes to desmosomes, linking clusters of desmosomal adhesion molecules to the intermediate filament cytoskeleton. Here, we generated Dp knockout (ko) cell lines of human keratinocytes to study the impact on desmosomal adhesion molecules and desmosome turnover using atomic force microscopy and superresolution imaging. In comparison to ko of another desmosomal component, plako...

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Literature Corpus work: a589dcf0-14e4-5b04-b54f-d84b5aea0604
DOI: 10.1101/2020.04.06.027185

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