Article
Regulation of the desmosome-intermediate filament linkage enables an adaptive mechano-response within the stratified epidermis
2026-08-31
Abstract excerpt
Skin, the bodys largest mechanosensitive organ, relies on a tension gradient across epidermal layers to maintain structure and function, but how mechanical force contributes to epidermal development and disease pathogenesis is poorly understood. By anchoring intermediate filaments (IF) to the plasma membrane, desmosomes, the most abundant intercellular junctions in the epidermis, help create a supracellular scaffo...
Identifiers and source
- Literature Corpus work
- e8a84b62-1928-539f-9f41-8e11f6d09216
- DOI
- 10.64898/2026.08.28.747586