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Desmosomes in Human Disease

24 Jan 2018

Abstract excerpt

Tissue integrity is crucial for maintaining the homeostasis of living organisms. Abnormalities that affect sites of cell-cell contact can cause a variety of debilitating disorders. The desmosome is an essential cell-cell junctional protein complex in tissues that undergo stress, and it orchestrates intracellular signal transduction. Desmosome assembly and junctional integrity are required to maintain the overall...

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PMID: 29414250
DOI: 10.1146/annurev-pathol-020117-044030

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