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Genotype-Dependent Morpho-Mechanical Profiling of Patient-Derived Human Myotubes on Nanogrooved Substrates.

Small (Weinheim an der Bergstrasse, Germany) - 1 Feb 2026

Crépin Raphaël, Aït Ouailal Anissa, Joanne Pierre, Agbulut Onnik, Mouly Vincent, Maciejak Olek, Malo Michel, Pelta Juan, Campillo Clément, Labdi Sid, Lamour Guillaume

Abstract excerpt

Muscle disorders such as myofibrillar myopathies and Duchenne muscular dystrophy involve mutations in key cytoskeletal proteins and lead to progressive muscle degeneration. Yet, the mechanical characterization of affected muscle cells has relied mainly on immature or non-human models. Here, we introduce a human in vitro platform based on patient-derived immortalized myoblasts differentiated into myotubes on...

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PMID: 41524654
DOI: 10.1002/smll.202511234

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AFM

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