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Article

Mutation in the Core Structure of Desmin Intermediate Filaments Affects Myoblast Elasticity.

Biophysical journal - 8 Aug 2017

Even Catherine, Abramovici Gilles, Delort Florence, Rigato Anna F, Bailleux Virginie, de Sousa Moreira Abel, Vicart Patrick, Rico Felix, Batonnet-Pichon Sabrina, Briki Fatma

Abstract excerpt

Elastic properties of cells are mainly derived from the actin cytoskeleton. However, intermediate filaments are emerging as major contributors to the mechanical properties of cells. Using atomic force microscopy, we studied the elasticity of mouse myoblasts expressing a mutant form of the gene encoding for desmin intermediate filaments, p.D399Y. This variant produces desmin aggregates, the main pathological...

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Identifiers

PMID: 28793217
DOI: 10.1016/j.bpj.2017.06.020
PMCID: PMC5549644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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