Article

The Desmosome is a Mesoscale Lipid Raft-Like Membrane Domain

2018-08-27

Abstract excerpt

<h4>Summary</h4> Desmogleins are cadherin family adhesion molecules essential for epidermal integrity. Previous studies have shown that desmogleins associate with lipid rafts, but the significance of this association was not clear. Here, we report that the desmoglein transmembrane domain (TMD) is the primary determinant of raft association. Further, we identify a novel mutation in the DSG1 TMD (G562R) that causes...

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Literature Corpus work: 8ac2b71e-29ae-5550-b152-076664732976
DOI: 10.1101/401455

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