Article
Desmoplakin is essential in epidermal sheet formation.
Nature cell biology - 1 Dec 2001
Vasioukhin V, Bowers E, Bauer C, Degenstein L, Fuchs E
Abstract excerpt
We have generated an epidermis-specific desmoplakin (DP) mouse knockout, and show that epidermal integrity requires DP; mechanical stresses to DP-null skin cause intercellular separations. The number of epidermal desmosomes in DP-null skin is similar to wild type (WT), but they lack keratin filaments, which compromise their function. DP-null keratinocytes have few desmosomes in vitro, and are unable to undergo...
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