Article
MHC molecules as peptide receptors.
Current opinion in immunology - 1 Feb 1993
Rammensee H G, Falk K, Rötzschke O
Abstract excerpt
The central unit for regulation of the specific immune system is a trimolecular complex made up of the T cell antigen receptor, the MHC molecule, and the MHC ligand. The third component is a peptide derived as a degradation product from a protein. During recent years there has been some progress in understanding the interaction between MHC molecules and their peptide ligands: MHC molecules are peptide receptors...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Antigen-Presenting Cells
- Binding Sites
- Biological Transport
- Epitopes
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
- Humans
- Models, Biological