Article

<i>MYCN</i> Amplification and <i>ATRX</i> Mutations are Incompatible in Neuroblastoma

2018-07-29

Abstract excerpt

<h4>SUMMARY</h4> Aggressive cancers often have activating mutations in growth-controlling oncogenes and inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the MYCN oncogene and inactivation of the ATRX tumor-suppressor gene correlate with high-risk disease and poor prognosis. Here we show that ATRX mutations and MYCN amplification are mutually exclusive across all ages and st...

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Literature Corpus work: 0252eb95-e47d-5120-8b21-35e30c41abc1
DOI: 10.1101/379636

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