Article

RRM2 is a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma

2020-11-26

Abstract excerpt

<h4>Summary</h4> Neuroblastoma is a pediatric tumor originating from the sympathetic nervous system responsible for 10-15 percent of all childhood cancer deaths. Half of all neuroblastoma patients present with high-risk disease at diagnosis. Despite intensive multi-modal therapies nearly 50 percent of high-risk cases relapse and die of their disease. In contrast to the overall paucity of mutations, high-risk neur...

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Literature Corpus work: 9d5f7b1f-0ac5-528c-826d-39a598262663
DOI: 10.1101/2020.11.25.397323

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