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Article

Hypoxia and hypoxia-inducible factors in neuroblastoma

14 Oct 2017

Abstract excerpt

Hypoxia (i.e., low oxygen levels) is a known feature of aggressive tumors. Cells, including tumor cells, respond to conditions of insufficient oxygen by activating a transcriptional program mainly driven by hypoxia-inducible factors (HIF)-1 and HIF-2. Both HIF-1α and HIF-2α expression levels have been shown to correlate to patient outcome in various tumor forms and in neuroblastoma, a solid childhood tumor of the...

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PMID: 29032465
DOI: 10.1007/s00441-017-2701-1

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