Article

Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cells

2018-09-21

Abstract excerpt

<h4>ABSTRACT</h4> Cellular senescence is a mechanism by which cells permanently withdraw from the cell cycle in response to stresses including telomere shortening, DNA damage, or oncogenic signaling. Senescent cells contribute to both age-related degeneration and hyperplastic pathologies, including cancer. In culture, normal human epithelial cells enter senescence after a limited number of cell divisions, known a...

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Literature Corpus work: 9ded8e09-0dbc-532a-b56a-6876cdb17a1a
DOI: 10.1101/423665

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