Article
Senescence Cell Induction Methods Display Diverse Metabolic Reprogramming and Reveal an Underpinning Serine/Taurine Reductive Metabolic Phenotype.
Aging cell - 1 Aug 2025
Berardi Domenica, Farrell Gillian, AlSultan Abdullah, McCulloch Ashley, Hall Nicole M, Sousa Rui Pedro Pereira, Jimenez Melanie, Selman Colin, Bellantuono Ilaria, Johnson Caroline H, Rattray Zahra, Rattray Nicholas J W
Abstract excerpt
The relationship between in vitro senescence cell induction and intracellular biomolecular dysregulation is still poorly understood. In this study, we have found that a range of metabolic subphenotypes exists and is dependent on the induction method that is used. To develop understanding of these subphenotypes, we developed and employed a novel bioanalytical pipeline integrating untargeted metabolomics,...
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