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Article

Targeting metabolism in cellular senescence, a role for intervention.

Molecular and cellular endocrinology - 5 Nov 2017

Nacarelli Timothy, Sell Christian

Abstract excerpt

Cellular senescence has gained much attention as a contributor to aging and susceptibility to disease. Senescent cells undergo a stable cell cycle arrest and produce pro-inflammatory cytokines. However, an additional feature of the senescence phenotype is an altered metabolic state. Despite maintaining a non-dividing state, senescent cells display a high metabolic rate. Metabolic changes characteristic of...

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PMID: 27591812
DOI: 10.1016/j.mce.2016.08.049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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