Article
Senescence-Associated Metabolomic Phenotype in Primary and iPSC-Derived Mesenchymal Stromal Cells.
Stem cell reports - 11 Feb 2020
Fernandez-Rebollo Eduardo, Franzen Julia, Goetzke Roman, Hollmann Jonathan, Ostrowska Alina, Oliverio Matteo, Sieben Torsten, Rath Björn, Kornfeld Jan-Wilhelm, Wagner Wolfgang
Abstract excerpt
Long-term culture of primary cells is characterized by functional and secretory changes, which ultimately result in replicative senescence. It is largely unclear how the metabolome of cells changes during replicative senescence and if such changes are consistent across different cell types. We have directly compared culture expansion of primary mesenchymal stromal cells (MSCs) and induced pluripotent stem...
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