Article

Nicotinamide Metabolism Reprogramming Drives Reversible Senescence of Glioblastoma Cells

2024-10-22

Abstract excerpt

Recent studies show that metabolites, beyond their metabolic roles, can induce significant changes in cell behavior. Herein, we investigate the non-canonical role of nicotinamide (vitamin B3) on glioblastoma (GB) cell behavior. Nicotinamide induced senescence in GB cells, characterized by reduced proliferation, chromatin reorganization, increased DNA damage, enhanced beta-galactosidase activity, and decreased Lami...

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Literature Corpus work: fe24ae75-b286-5c21-8d58-00a044ec5f1b
DOI: 10.1101/2024.10.18.619131

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