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Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cells

28 May 2019

Abstract excerpt

Cellular senescence is a mechanism by which cells permanently withdraw from the cell cycle in response to stresses including telomere shortening, DNA damage, or oncogenic signaling. Senescent cells contribute to both age-related degeneration and hyperplastic pathologies, including cancer. In culture, normal human epithelial cells enter senescence after a limited number of cell divisions, known as replicative...

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PMID: 31138644
DOI: 10.1074/jbc.ra118.005806

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