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Article

Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming

1 Aug 2019

Abstract excerpt

Reprogrammed metabolism and cell cycle dysregulation are two cancer hallmarks. p16 is a cell cycle inhibitor and tumor suppressor that is upregulated during oncogene-induced senescence (OIS). Loss of p16 allows for uninhibited cell cycle progression, bypass of OIS, and tumorigenesis. Whether p16 loss affects pro-tumorigenic metabolism is unclear. We report that suppression of p16 plays a central role in...

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PMID: 31433975
DOI: 10.1016/j.celrep.2019.07.084

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