Article

A Toxic Tau-PFKFB3 Circuit Reduces F2,6BP Levels and Drives Neurodegeneration

2026-05-31

Abstract excerpt

<h4>Summary</h4> Alzheimer’s disease (AD) and related dementias are progressive neurodegenerative disorders manifested by aggregation of Tau and Amyloid beta (Aβ). Emerging evidence suggests that metabolic dysregulation contributes to AD pathogenesis, yet how metabolic alterations interface with neuronal integrity remains unclear. Here, we identify dysfunction in PFKFB3-F2,6BP (fructose-2,6-bisphosphate) metaboli...

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Literature Corpus work: c5d4f866-5fb1-56e8-bd87-ffce6232357f
DOI: 10.64898/2026.05.28.728580

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