Article

Hyperactive mTOR in Lung Mesenchyme Induces Endothelial Dysfunction and Pulmonary Vascular Remodeling

2022-10-08

Abstract excerpt

Pulmonary vascular remodeling is the key structural abnormality in pulmonary hypertension (PH). Mechanistic target of rapamycin (mTOR) has long been suspected to play a role in the development of pulmonary vascular remodeling. However, underlying cellular and molecular mechanisms leading to this pathophysiological condition remain incompletely understood. To elucidate the crosstalk between lung mesenchyme with act...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9ddf3657-21a9-5cf8-8633-6dd798c38a62
DOI: 10.1101/2022.10.08.511300

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hyperactive mTOR in Lung Mesenchyme Induces Endothelial Dysfunction and Pulmonary Vascular RemodelingDOI 10.1101/2022.10.08.511300Read

Hyperactive mTORC1 in lung mesenchyme induces endothelial cell dysfunction and pulmonary vascular remodelingSemantic proximity Read

mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function declineSemantic proximity Read

Active mTOR in Lung Epithelium Promotes Epithelial-Mesenchymal Transition and Enhances Lung Fibrosis.Semantic proximity Read

Extracellular Matrix-Induced Genes May Reduce Response to Rapamycin in LAMSemantic proximity Read

Lymphangioleiomyomatosis (LAM): molecular insights lead to targeted therapies.Semantic proximity Read

Molecular Pathogenesis of LymphangioleiomyomatosisSemantic proximity Read

STAT1 Promotes PD-L1 Activation and Tumor Growth in LymphangioleiomyomatosisSemantic proximity Read

Targeting Fibroblast-Endothelial Interactions in LAM Pathogenesis: 3D Spheroid and Spatial Transcriptomic Insights for Therapeutic InnovationSemantic proximity Read

Decoding Lymphangioleiomyomatosis (LAM) Niche Environment via Integrative Analysis of Single Cell Multiomics and Spatial TranscriptomicsSemantic proximity Read

Lymphangioleiomyomatosis: where endocrinology, immunology and tumor biology meetSemantic proximity Read

Lymphangioleiomyomatosis: pathogenesis, clinical features, diagnosis, and management.Semantic proximity Read

Lymphangioleiomyomatosis: Current understanding and potential treatments.Semantic proximity Read