Article

Extracellular Matrix-Induced Genes May Reduce Response to Rapamycin in LAM

2024-05-19

Abstract excerpt

<h4>Rationale</h4> Lymphangioleiomyomatosis (LAM) is a rare cystic lung disease driven by nodules containing TSC2 -/- ‘LAM cells’ and recruited LAM associated fibroblasts (LAFs). Although rapamycin reduces lung function loss, some patients continue to decline meaning additional therapies are needed. <h4>Objectives</h4> To investigate how the LAM nodule environment affects LAM cell proliferation and the respons...

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Literature Corpus work: 1cb7e0f8-f548-517f-95db-c5a909c6185d
DOI: 10.1101/2024.05.16.594484

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