Article
Lymphangioleiomyomatosis (LAM): molecular insights lead to targeted therapies.
Respiratory medicine - 1 Jul 2010
Glasgow Connie G, Steagall Wendy K, Taveira-Dasilva Angelo, Pacheco-Rodriguez Gustavo, Cai Xiong, El-Chemaly Souheil, Moses Marsha, Darling Thomas, Moss Joel
Abstract excerpt
LAM is a rare lung disease, found primarily in women of childbearing age, characterized by cystic lung destruction and abdominal tumors (e.g., renal angiomyolipoma, lymphangioleiomyoma). The disease results from proliferation of a neoplastic cell, termed the LAM cell, which has mutations in either of the tuberous sclerosis complex (TSC) 1 or TSC2 genes. Molecular phenotyping of LAM patients resulted in the...
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