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Article

mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline

6 Nov 2020

Abstract excerpt

Lymphangioleiomyomatosis (LAM) is a rare fatal cystic lung disease due to bi-allelic inactivating mutations in tuberous sclerosis complex (TSC1/TSC2) genes coding for suppressors of the mechanistic target of rapamycin complex 1 (mTORC1). The origin of LAM cells is still unknown. Here, we profile a LAM lung compared to an age- and sex-matched healthy control lung as a hypothesis-generating approach to identify...

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PMID: 33159078
DOI: 10.1038/s41467-020-18979-4

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