Article
Active mTOR in Lung Epithelium Promotes Epithelial-Mesenchymal Transition and Enhances Lung Fibrosis.
American journal of respiratory cell and molecular biology - 1 Jun 2020
Saito Minako, Mitani Akihisa, Ishimori Taro, Miyashita Naoya, Isago Hideaki, Mikami Yu, Noguchi Satoshi, Tarui Megumi, Nagase Takahide
Abstract excerpt
The mTOR pathway is one of the key signal cascades in the pathogenesis of idiopathic pulmonary fibrosis. Previous studies have mainly focused on this pathway in the fibroblasts and/or myofibroblasts, but not in the epithelial cells. In this study, we sought to investigate the role of the mTOR pathway in lung epithelial cells in lung fibrosis. Using Sftpc-mTORSL1+IT transgenic mice, in which active mTOR is...
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