Article
Decoding Lymphangioleiomyomatosis (LAM) Niche Environment via Integrative Analysis of Single Cell Multiomics and Spatial Transcriptomics
2025-07-10
Abstract excerpt
Lymphangioleiomyomatosis (LAM) is a rare, progressive lung disease characterized by cystic destruction and metastatic growth of smooth muscle-like cells. Despite advances in understanding its genetic basis, the cellular heterogeneity, regulatory mechanisms, and microenvironmental interactions driving LAM progression remain poorly defined. In this study, we employed an integrative multi-omics approach combining sin...
Topics
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- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
- Extracellular vesicles in disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Renal and related cancers
- Reproductive System and Pregnancy
- Respiratory viral infections research
- Tuberous Sclerosis Complex Research
Identifiers and source
- Literature Corpus work
- 068c2e7b-bf7f-5600-b118-f2a2c2ec725f
- DOI
- 10.1101/2025.07.07.663390