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Article

Molecular Pathogenesis of Lymphangioleiomyomatosis

13 Nov 2006

Abstract excerpt

Lymphangioleiomyomatosis (LAM) is a rare progressive cystic lung disease affecting young women. The pivotal observation that LAM occurs both spontaneously and as part of the tuberous sclerosis complex (TSC) led to the hypothesis that these disorders share common genetic and pathogenetic mechanisms. In this review we describe the evolution of our understanding of the molecular and cellular basis of LAM and TSC,...

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Share to Myeloproliferative Neoplasms: Diagnosis and Treatment
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PMID: 17099139
DOI: 10.1165/rcmb.2006-0372tr

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