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Rapid decay of host basal mRNAs during SARS-CoV-2 infection perturbs host antiviral mRNA biogenesis and export

2021-04-19

Abstract excerpt

A key feature of the mammalian innate immune response to viral infection is the transcriptional induction of interferon (IFN) genes, which encode for secreted proteins that prime the antiviral response and limit viral replication and dissemination. A hallmark of severe COVID-19 disease caused by SARS-CoV-2 is the low presence of IFN proteins in patient serum despite elevated levels of IFN -encoding mRNAs, indicat...

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Identifiers and source

Literature Corpus work
9dc189d8-c88e-5569-b252-7ba1166d29a4
DOI
10.1101/2021.04.19.440452
Open publication

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Rapid decay of host basal mRNAs during SARS-CoV-2 infection perturbs host antiviral mRNA biogenesis and exportDOI 10.1101/2021.04.19.440452
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