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Article

The main protease of SARS-CoV-2 downregulates innate immunity via a translational repression

13 Apr 2023

Abstract excerpt

SARS-CoV-2 is the etiological cause of COVID-19. RIG-I-like receptor (RLR) signaling pathway appeared to be responsible for SARS-CoV-2 induced IFN, 1 a major antiviral pathway. IFN deficiency 2 , 3 was identified to be a significant risk factor of severe COVID-19, highlighting an important role of IFN in the defense against SARS-CoV-2 and in the pathogenesis of severe COVID-19. Since SARS-CoV-2 is highly...

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PMID: 37055405
DOI: 10.1038/s41392-023-01418-3

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