Article

Why are G-quadruplexes good at preventing protein aggregation?

2022-08-23

Abstract excerpt

Maintaining a healthy protein folding environment is essential for cellular function. Recently, we found that nucleic acids, and G-quadruplexes in particular, are potent chaperones for preventing protein aggregation. With the aid of structure-function and NMR analyses of two G-quadruplex forming sequences, PARP-I and LTR-III, we uncovered several contributing factors that affect G-quadruplexes in preventing protei...

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Literature Corpus work: 9d847e14-2cdf-5b5f-8243-718817eb9d80
DOI: 10.1101/2022.08.23.504968

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