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Article

Oxidative damage diminishes mitochondrial DNA polymerase replication fidelity.

Nucleic acids research - 24 Jan 2020

Anderson Andrew P, Luo Xuemei, Russell William, Yin Y Whitney

Abstract excerpt

Mitochondrial DNA (mtDNA) resides in a high ROS environment and suffers more mutations than its nuclear counterpart. Increasing evidence suggests that mtDNA mutations are not the results of direct oxidative damage, rather are caused, at least in part, by DNA replication errors. To understand how the mtDNA replicase, Pol γ, can give rise to elevated mutations, we studied the effect of oxidation of Pol γ on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31799610
DOI: 10.1093/nar/gkz1018
PMCID: PMC6954441

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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