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Mechanisms of DNA damage and insight into mutations by chromium(VI) in the presence of glutathione.

Journal of inorganic biochemistry - 1 Jan 2007

Mazzer Paula A, Maurmann Leila, Bose Rathindra N

Abstract excerpt

The mechanisms of hexavalent chromium(VI) induced DNA damage were unveiled by detecting products of single- and double-stranded DNA in the presence of glutathione. The absence of a detectable hydroxyl radical in the reactions indicates that DNA damage was exclusively by hypervalent chromium species. Polyacrylamide gel electrophoresis (PAGE) experiments with 32-mer single-stranded oligonucleotide and its...

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Identifiers

PMID: 17011629
DOI: 10.1016/j.jinorgbio.2006.08.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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