Article

Advances in Fluorescence Detection Methods for the Local Generation of Hydroxyl Radicals Near DNA and Within Organelles and Membranes

2024-12-23

Abstract excerpt

Hydroxyl radicals (•OH), the most potent oxidants among reactive oxygen species (ROS), are a major contributor to oxidative damage of biomacromolecules including DNA, lipids, and proteins. The overproduction of •OH is implicated in the pathogenesis of numerous diseases such as cancer, neurodegenerative disorders, and some cardiovascular pathologies. Given the localized nature of •OH-induced damage, detecting •OH,...

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Literature Corpus work: fa1ed224-6076-5fed-895c-feb6f0362da8
DOI: 10.20944/preprints202412.1941.v1

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