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Article

Changes in metabolic landscapes shape divergent but distinct mutational signatures and cytotoxic consequences of redox stress.

Nucleic acids research - 9 Jun 2023

Degtyareva Natalya P, Placentra Victoria C, Gabel Scott A, Klimczak Leszek J, Gordenin Dmitry A, Wagner Brett A, Buettner Garry R, Mueller Geoffrey A, Smirnova Tatyana I, Doetsch Paul W

Abstract excerpt

Mutational signatures discerned in cancer genomes, in aging tissues and in cells exposed to toxic agents, reflect complex processes underlying transformation of cells from normal to dysfunctional. Due to its ubiquitous and chronic nature, redox stress contributions to cellular makeover remain equivocal. The deciphering of a new mutational signature of an environmentally-relevant oxidizing agent, potassium...

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Identifiers

PMID: 37078607
DOI: 10.1093/nar/gkad305
PMCID: PMC10250236

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