Article

Genome-wide mapping of 5ʹ-aldehyde terminus induced by reactive oxygen species

2025-02-23

Abstract excerpt

DNA single strand breaks (SSBs) are abundant lesions due to cell metabolism and reactive oxygen species (ROS) and can lead to replication folk collapse, double strand break formation, genome rearrangements, cell death and disease. Among numerous chemical forms of SSBs, 5ʹ-aldehyde terminus are the most abundant generated by hydroxyl radicals and pose significant challenge for cellular repair machinery due to the l...

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Literature Corpus work: 4581e499-9e0d-5e01-a384-a57dc23508b8
DOI: 10.1101/2025.02.19.636396

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