Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deletion of the Snord116/SNORD116 Alters Sleep in Mice and Patients with Prader-Willi Syndrome.

Sleep - 1 Mar 2016

Lassi Glenda, Priano Lorenzo, Maggi Silvia, Garcia-Garcia Celina, Balzani Edoardo, El-Assawy Nadia, Pagani Marco, Tinarelli Federico, Giardino Daniela, Mauro Alessandro, Peters Jo, Gozzi Alessandro, Grugni Graziano, Tucci Valter

Abstract excerpt

STUDY OBJECTIVES: Sleep-wake disturbances are often reported in Prader-Willi syndrome (PWS), a rare neurodevelopmental syndrome that is associated with paternally-expressed genomic imprinting defects within the human chromosome region 15q11-13. One of the candidate genes, prevalently expressed in the brain, is the small nucleolar ribonucleic acid-116 (SNORD116). Here we conducted a translational study into the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circadian Rhythm
Share to Electroencephalography

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gray Matter

Share to Paternal Inheritance

Share to Prader-Willi Syndrome

Share to RNA, Small Nucleolar

Share to Sleep, REM

Source

Open in PubMed Open full text

Identifiers

PMID: 26446116
DOI: 10.5665/sleep.5542
PMCID: PMC4763347

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletion of the Snord116/SNORD116 Alters Sleep in Mice and Patients with Prader-Willi Syndrome.PMID 26446116Read ↗

Loss of Snord116 alters cortical neuronal activity in mice: a preclinical investigation of Prader-Willi syndrome.Semantic proximity Read ↗

The paternally imprinted gene <i>Snord116</i> regulates cortical neuronal activitySemantic proximity Read ↗

Loss of SNORD115 mitigates SNORD116-driven sleep abnormalities in mouse models of Prader-Willi syndromeSemantic proximity Read ↗

Maternal transcription of non-protein coding RNAs from the PWS-critical region rescues growth retardation in mice.Semantic proximity Read ↗

Loss of the imprinted, non-coding Snord116 gene cluster in the interval deleted in the Prader Willi syndrome results in murine neuronal and endocrine pancreatic developmental phenotypes.Semantic proximity Read ↗

Evolutionary and biological insights into the paternally expressed Snord116-Ipw-Snord115 gene array at the imprinted Prader-Willi syndrome domainSemantic proximity Read ↗

<i>Snord116</i> -dependent diurnal rhythm of DNA methylation in mouse cortexSemantic proximity Read ↗

Prader-Willi locus <i>Snord116</i> RNA processing requires an active endogenous allele and neuron-specific splicing by <i>Rbfox3/NeuN</i>Semantic proximity Read ↗

Comparison of mouse models reveals a molecular distinction between psychotic illness in PWS and schizophreniaSemantic proximity Read ↗

Prader-Willi locus Snord116 RNA processing requires an active endogenous allele and neuron-specific splicing by Rbfox3/NeuN.Semantic proximity Read ↗

Paternally expressed imprinted <i>Snord116</i> and <i>Peg3</i> regulate hypothalamic orexin neuronsSemantic proximity Read ↗

Behavioural characteristics of the Prader-Willi syndrome related biallelic Snord116 mouse model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.