Article

Subcellular partitioning of <i>Nhlh2</i> mRNA reveals how <i>SNORD116</i> loss contributes to Prader-Willi Syndrome

2026-01-23

Abstract excerpt

<h4>Summary</h4> Deletion of the SNORD116 non-coding RNA is associated with the development of Prader-Willi Syndrome (PWS). We and others have identified NHLH2/Nhlh2 as a putative SNORD116/Snord116 target and in this study report that Nhlh2 and Snord116 are co-expressed in forebrain neurons. Nhlh2 mRNA is found predominantly in the nucleus of Snord116+ hypothalamic neurons but is evenly distributed between...

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Literature Corpus work: d1cbd705-96db-5a48-af41-b3a9fc1aa8f1
DOI: 10.64898/2026.01.20.700624

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