Article

Tumor-derived FXII engages the intrinsic coagulation cascade to support breast cancer liver metastasis

2026-06-08

Abstract excerpt

Metastasis is the leading cause of death in breast cancer, yet the mechanisms controlling organotropism are not well defined. Coagulation has emerged as a biologically relevant contributor to metastatic progression, but mechanisms linking pro-thrombotic phenotypes to organ-specific metastasis remain unresolved, significantly hindering the development of novel treatments. Here, a serial transplantation approach was...

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Literature Corpus work: 9d2e4f33-a557-5db0-bf06-3a2f1c2f64f0
DOI: 10.64898/2026.06.03.729507

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