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Tissue factor pathway inhibitor-2 (TFPI-2)—an underappreciated partaker in cancer and metastasis

17 Aug 2024

Abstract excerpt

The coagulation system is known to play an important role in cancer development and metastasis, but the precise mechanisms by which it does so remain incompletely understood. With this in mind, we provide an updated overview of the effects of TFPI-2, a protease inhibitor, on cancer development and metastasis. TFPI-2 interacts with the thrombin cascade and also employs other mechanisms to suppress cancer growth...

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Blood Coagulation and Thrombosis Mechanisms
Protease and Inhibitor Mechanisms
Signaling Pathways in Disease

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39153052
DOI: 10.1007/s10555-024-10205-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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