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Article

Primary tumor–derived systemic nANGPTL4 inhibits metastasis

21 Oct 2022

Abstract excerpt

Primary tumors and distant site metastases form a bidirectionally communicating system. Yet, the molecular mechanisms of this crosstalk are poorly understood. Here, we identified the proteolytically cleaved fragments of angiopoietin-like 4 (ANGPTL4) as contextually active protumorigenic and antitumorigenic contributors in this communication ecosystem. Preclinical studies in multiple tumor models revealed that the...

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PMID: 36269299
DOI: 10.1084/jem.20202595

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