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Article

Murine coagulation factor VIII is synthesized in endothelial cells

10 Apr 2014

Abstract excerpt

The primary cellular source of factor VIII (FVIII) biosynthesis is controversial, with contradictory evidence supporting an endothelial or hepatocyte origin. LMAN1 is a cargo receptor in the early secretory pathway that is responsible for the efficient secretion of factor V (FV) and FVIII to the plasma. Lman1 mutations result in combined deficiency of FV and FVIII, with levels of both factors reduced to ~10% to...

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PMID: 24719406
DOI: 10.1182/blood-2014-02-554501

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