Article

Breast Cancer Remodels Lymphatics in Sentinel Lymph Nodes

2024-12-30

Abstract excerpt

<h4>ABSTRACT</h4> Cancer metastasis to sentinel lymph nodes (LNs) is often the first marker of potential disease progression. Although it is recognized that tumor-induced lymphangiogenesis facilitates metastasis into LNs in murine models, tumor-induced alterations in human lymphatic vessels remain obscure. We used single-cell RNA sequencing to profile lymphatic endothelial cell (LEC) subsets in paired metastatic...

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Literature Corpus work: 3842429a-fa93-51a3-9bb7-1a199dda6dd1
DOI: 10.1101/2024.12.30.630756

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