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Separation of breast cancer and organ microenvironment transcriptomes in metastases

6 Mar 2019

Abstract excerpt

BACKGROUND: The seed and soil hypothesis was proposed over a century ago to describe why cancer cells (seeds) grow in certain organs (soil). Since then, the genetic properties that define the cancer cells have been heavily investigated; however, genomic mediators within the organ microenvironment that mediate successful metastatic growth are less understood. These studies sought to identify cancer- and...

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PMID: 30841919
DOI: 10.1186/s13058-019-1123-2

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